Holding Back Time with Dr. Amanda Holden

September 12, 2025

The future of aesthetics is here. Dr. Amanda Holden reveals why Sculptra is replacing fillers & what's coming in 2026.

In this comprehensive conversation, Dr. Georgine Nanos interviews Dr. Amanda Holden, founder and CEO of Holden Timeless Beauty and nationally recognized leader in medical aesthetics. Dr. Holden shares the biggest trends transforming the industry, from bio-stimulators like Sculptra to revolutionary energy-based treatments like M-FACE.

Dr. Holden breaks down the science behind why patients are choosing Sculptra as their foundation treatment, how it differs from traditional hyaluronic acid fillers, and why the industry is moving toward natural, long-lasting results. She also reveals cutting-edge regenerative medicine treatments coming from Korea and what the next decade holds for aesthetic medicine.

Key Takeaways

  • Why Sculptra is becoming the gold standard bio-stimulator
  • How M-FACE technology lifts and tones without surgery
  • The truth about filler safety and longevity
  • Future of regenerative medicine in aesthetics
  • How to choose the right aesthetic provider
  • Treatment combinations that actually work
  • What's coming in 2026 and beyond
  • Growth factors vs PRP vs exosomes explained
  • Neck treatment options and realistic outcomes

Timestamps

01:23 - Biggest trends in aesthetics right now
02:16 - What is Sculptra and how it works
04:49 - Sculptra vs hyaluronic acid fillers
08:49 - The shift toward natural aesthetic results
12:38 - Treatment planning and realistic expectations
15:37 - Aesthetics and wellness convergence
19:19 - GLP-1 medications and "Ozempic face"
20:51 - M-FACE technology breakdown
25:19 - Neck treatment strategies and limitations
27:41 - Future trends in aesthetics for 2026
28:51 - Growth factors, PRP, and exosomes explained
32:19 - Stem cell sourcing and safety concerns
34:29 - Dr. Holden's journey from ER to aesthetics
42:22 - Lightning round: Industry insights

The information provided in this video and accompanying show notes is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare provider for personalized medical recommendations. The content discussed represents general principles and may not apply to every individual's situation.

Meet the Author

About Dr. Nanos

You might also enjoy:

Podcast cover: “An Honest Conversation About TMS” with two doctors in business and white coats on a blue background

TMS Is a Crane. You Still Have to Climb the Mountain. — An Honest Conversation About TMS

September 28, 2026
Dr. Georgine Nanos sits down with Kyle Hartfield, founder of iTalk TMS, a patient-facing advocacy platform he built because he could not stand a minute of the existing content about it.
Podcast promo with two doctors and title “Who Do You Want to Be When You Die?”

"Who Do You Want to Be When You Die?" — Dr. James Ross on Reverse-Engineering a Life

September 23, 2026
Dr. Georgine Nanos sits down with Dr. James Ross, who practices what he prefers to call holistic brain health.
Gloved hands holding a red test tube in a lab with colorful vials in a rack

Colorectal cancer is moving into people in their 30s and 40s, and the intervention is not a new test.

September 21, 2026
Colorectal cancer is climbing 3% a year in adults under 50, and younger patients are nearly twice as likely to be diagnosed at stage 4. A UC San Diego surgeon on why, and the two words that fix most of it.

You Are Not Too Young for This — A Surgeon on the Cancer That Moved Into Your Thirties

September 14, 2026
Colorectal cancer used to be an older person's disease. It is not anymore. Dr. Nanos sits down with Sonia Ramamoorthy, they get into why it keeps getting caught late, and the answer is uncomfortable. The early symptoms are rectal bleeding and a change in bowel habits.